Pioglitazone improves whole‐body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome
نویسندگان
چکیده
AIMS/INTRODUCTION Low aerobic capacity is a strong and independent predictor of all-cause mortality in patients with metabolic syndrome (MetS). Here, we investigated the effects of pioglitazone treatment on whole-body aerobic capacity and skeletal muscle energy metabolism in MetS patients. MATERIALS AND METHODS A total of 14 male patients with MetS received oral pioglitazone 15 mg/day for 4 months. To assess whole-body aerobic capacity, exercise testing with a bicycle ergometer was carried out before and after pioglitazone treatment. To assess skeletal muscle energy metabolism, intramyocellular lipid in the resting leg and high-energy phosphates in the calf muscle during plantar-flexion exercise were measured using 1 proton- and 31 phosphorus magnetic resonance spectroscopy, respectively. RESULTS Pioglitazone significantly increased peak oxygen uptake (25.1 ± 4.9 mL/kg/min pretreatment vs 27.2 ± 3.9 mL/kg/min post- treatment, P < 0.05) and anaerobic threshold (12.7 ± 1.9 mL/kg/min pretreatment vs 13.6 ± 1.6 mL/kg/min post-treatment, P < 0.05), although daily physical activity was comparable before and after the treatment. Intramyocellular lipid content was significantly reduced after pioglitazone treatment by 26%, indicating improved skeletal muscle fatty acid metabolism. Pioglitazone also significantly decreased the muscle phosphocreatine loss during exercise by 13%, indicating improved skeletal muscle high-energy phosphate metabolism. Notably, the increase in anaerobic threshold; that is, submaximal aerobic capacity, closely correlated with the decrease in intramyocellular lipid content after pioglitazone treatment. CONCLUSIONS Pioglitazone significantly improved the MetS patients' whole-body aerobic capacity and skeletal muscle energy metabolism. The beneficial effect of pioglitazone on whole-body aerobic capacity might be at least in part through improved fatty acid metabolism in the skeletal muscle.
منابع مشابه
Systemic Oxidative Stress Is Associated With Lower Aerobic Capacity and Impaired Skeletal Muscle Energy Metabolism in Patients With Metabolic Syndrome
OBJECTIVE Systemic oxidative stress is associated with insulin resistance and obesity. We tested the hypothesis that systemic oxidative stress is linked to lower aerobic capacity and skeletal muscle dysfunction in metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS The incremental exercise testing with cycle ergometer was performed in 14 male patients with MetS and 13 age-, sex-, and activ...
متن کاملAerobic-Strength Exercise Improves Metabolism and Clinical State in Parkinson’s Disease Patients
Regular exercise ameliorates motor symptoms in Parkinson's disease (PD). Here, we aimed to provide evidence that exercise brings additional benefits to the whole-body metabolism and skeletal muscle molecular and functional characteristics, which might help to explain exercise-induced improvements in the clinical state. 3-months supervised endurance/strength training was performed in early/mid-s...
متن کاملEFFECT OF AEROBIC TRAINING AND ETHANOL CONSUMPTION ON LIPID PROFILE AND GENE EXPRESSION OF SOME GASTROCNEMIUS MUSCLE MYOKINES IN MALE RATS
Background: Skeletal muscle as an endocrine tissue is involved in the regulation of metabolic activity, production and secretion of hormones including myokines. The aim of the present study was to investigate the effect of eight weeks of aerobic training combined with ethanol consumption on plasma lipid profile and glucose levels, triglyceride content and mayonectin, irisin and leptin gene expr...
متن کاملDeletion of Kinin B2 Receptor Alters Muscle Metabolism and Exercise Performance
Metabolic syndrome is a cluster of metabolic risk factors such as obesity, diabetes and cardiovascular diseases. Mitochondria is the main site of ATP production and its dysfunction leads to decreased oxidative phosphorylation, resulting in lipid accumulation and insulin resistance. Our group has demonstrated that kinins can modulate glucose and lipid metabolism as well as skeletal muscle mass. ...
متن کاملEffect of Aerobic Training Program on Obesity and Insulin Resistance in Young Women with Polycystic Ovary Syndrome
OBJECTIVE: Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age characterized by the presence of polycystic ovaries, menstrual dysfunction and biochemical or clinical hyperandrogenism. Lifestyle modification is important in treatment of obese and overweight women with PCOS. This study was performed to evaluate the benefit of aerobic exercise training o...
متن کامل